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Lower your miscarriage risk with new tests, treatments

  • Story Highlights
  • 15 to 50 percent of all pregnancies end in miscarriage
  • To help avoid miscarriage, know your risk factors (diabetes, fibroids, etc)
  • If you've miscarried, consider chromosome analysis of the fetal tissue
  • Most women who've miscarried go on to have healthy babies
  • Next Article in Health »
By Amy Paturel
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When Kori Morrison had her first miscarriage, she and her husband, Tom, were upset but still hopeful. After all, she knew that 15 to 50 percent of all pregnancies end in miscarriage, and most of these women who've miscarried go on to have healthy babies. But in the next eight years, Morrison had four more miscarriages. Sadness and self-blame set in. "I wondered if I was eating the wrong things, if I was overstressed, or, worst of all, if my body just wasn't cut out for pregnancy," she says.

Morrison was eventually found to have a hormone imbalance: Low progesterone during pregnancy kept her uterus from nourishing the embryo. With treatment, she went on to have four children.

Although Morrison went through agony for years before discovering what was wrong, her story illustrates that there are ways to identify what causes miscarriages and what can be done to prevent them. Important to know because, while most women will go on to have a successful pregnancy, about 5 percent are likely to lose another baby. And the use of assisted reproductive technology such as in vitro fertilization (common among women 35-plus) seems to boost miscarriage risks even more.

1. Do a little detective work

When you're planning to get pregnant, your first move should be a careful prepregnancy checkup to reveal potential risk factors like diabetes-related problems, high blood pressure, polycstic ovary syndrome, fibroids, or thyroid abnormalities -- all of which are mostly treatable, says Mary Stephenson, M.D., professor of obstetrics and gynecology and director of the recurrent-pregnancy-loss program at the University of Chicago Medical Center. Simple steps can help when you're having trouble getting pregnant

Go over your medical history with your doctor, and also mention any medications, herbs, and supplements you are taking. You might learn something about potentially risky non-prescription meds such as ibuprofen or herbs such as ginkgo. Even taking a little time to discuss a family history of miscarriages with your doctor might uncover a correctable problem.

2. Stop the stress

We've all heard that being stressed isn't a good thing if you're trying to get pregnant. That's also true of trying to stay pregnant. British researchers recently found that feeling happy, relaxed, or in control is linked to a 60 percent reduction in a woman's miscarriage risk. What helps when you can't kick back with a glass of wine? Gentle workouts, dining with friends, or watching your favorite TV show might work (stick with The Office instead of nerve-janglers like 24 or ER). The Pill is dangerous, and other myths

And what about sex? If you've had a miscarriage in the past, says Jonathan Scher, M.D., assistant clinical professor of obstetrics and gynecology at Mount Sinai Medical Center in New York, it's probably best to skip nookie during your first trimester, when a hormone in semen may stimulate contractions. It's OK later, after the embryo is fully implanted. Is your fertility window closing?

3. Do some chromosome testing

After a miscarriage, a chromosome analysis of fetal tissue can provide some useful information, says Scher.

The test can reveal if there was an unavoidable chromosome problem -- the cause of as many as 50 percent of miscarriages. If the test result is abnormal (the tissue has an abnormal number of chromosomes), it's good news. This is a random event, and the chance of it happening again is no higher than normal. Time to try again. A normal test result, however, may require further investigation (there's more information on this in "Take a Few More Tests," below).

Unless you insist, you may not be offered chromosome analysis. "It's the most important thing we can do," Stephenson says, "But, unfortunately, it's very seldom done."

Why? Medical guidelines don't recommend it unless you've had multiple miscarriages. Even then, if you're healthy, doctors might beg off. But Scher and Stephenson advise any woman who has two or more miscarriages to get the test. A calendar method that works

4. Take a few more tests

If the chromosomes are normal and it's your second or third miscarriage, there's a good chance you have a fixable problem. But you won't find out without additional tests. You might be screened for a genetic tendency for blood clots, a weak cervix, a hormonal imbalance, or even an autoimmune problem such as lupus. If you have a blood-clotting disorder, anticlotting medication may cut your risk of miscarriage by up to 75 percent. If it's a weak cervix, a stitch applied at the end of the first trimester can prevent the cervix from opening early and starting premature labor.

To uncover these kinds of problems, you may need to go to a specialized, recurrent-pregnancy-loss clinic, Stephenson says. Most important, though, keep pushing for answers. That's what Darci Klein did after suffering three miscarriages, including the loss of twins at 20 weeks. Eventually, tests showed she had an inherited blood-clotting disorder and a weak cervix. After treatment -- injections of a blood thinner and a cervical stitch -- she carried a pregnancy to term and gave birth to a healthy baby boy. "You don't ever get over losing a child," says Klein, author of "To Full Term: A Mother's Triumph Over Miscarriage." "But you need to ask for testing." E-mail to a friend E-mail to a friend

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Copyright Health Magazine 2009

All About Pregnancy and Childbirth

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