The story

John Symons lost his wife Jo to a mysterious cancer two years ago. But he isn't done battling the disease.

Jo suffered from cancer of unknown primary, or CUP, a diagnosis that is given when doctors find cancer in the body but aren't able to identify where it began.

That inevitably complicates treatment, as doctors are at a loss as to whether they are dealing with breast, lung or countless other types of cancer.

"Any cancer diagnosis is devastating for patients and loved ones. But not knowing where in the body the cancer has originated and what type of cancer we are dealing with is a double blow, it's double agony," Symons told CNN.

After his wife died in 2006, Symons abandoned his career as a business school professor to set up the Cancer of Unknown Primary Foundation, also known as "Jo's friends." Read full article »

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