(CNN) -- Defending champions Barcelona are out of the Spanish Cup despite beating Sevilla 1-0 in their last 16 second leg clash.
The only goal came in the 64th minute when Xavi Hernandez chested down Ndri Romaric's weak clearance to curl a shot past the outstretched Andres Palop.
Pep Guardiola's side battled for a second goal, as Lionel Messi hit the post and Zlatan Ibrahimovic missed an open goal.
Barcelona had won every competition they had competed in since Guardiola's arrival before the start of the 2008-2009 season, lifting an unprecedented six major trophies along the way.
But their 2-1 first leg defeat at the Nou Camp meant that Sevilla advanced to the quarterfinals on the away goals rule.
Meanwhile, Filipe scored one goal and set up another to help Deportivo La Coruna battle back to draw 2-2 at home to Valencia for a 4-3 aggregate victory.
Croatian striker Nikola Zigic scored a pair of headers to put 2008 winners Valencia in control in the first half.
But defender Filipe, playing out of position in midfield, made it 3-3 on aggregate in the 50th minute when he poked the ball past goalkeeper Miguel Angel Moya.
And the Brazilian then squared the ball for Juan Rodriguez to steer the ball home with 18 minutes remaining.
The result means Deportivo will now face Sevilla over two legs with the winners through to the semifinals.