- Reigning champion Andy Murray beaten in second round of Aegon Championships at Queen's Club
- Top seed beaten by France's Nicolas Mahut, 6-3, 6-7 (4-7), 7-6 (7-1)
- Four-time champion Andy Roddick beaten by France's Edouard Roger-Vasselin
- Number one seed Francesca Schiavone beaten by Japan's Miskai Dothe in WTA Aegon Classic
Top seed and reigning champion Andy Murray crashed out of the Aegon Championships at Queen's Club.
The world number four suffered a shock second-round defeat to France's Nicolas Mahut, who won 6-3, 6-7 (4-7), 7-6 (7-1).
Four-time champion Andy Roddick also crashed out at the second round stage, as France's Edouard Roger-Vasselin clinched a shock 6-4, 4-6, 7-5 victory over the seventh seed.
Murray had won the traditional Wimbledon warm-up tournament twice in the last three years, but made a series of errors on his way to defeat against Mahut.
Defeat leaves the Scot without a title since his triumph in Brisbane in January, but Murray insisted there were positives to take from defeat.
"I don't think it went all wrong. It was a very close match but losing serve in the third set after breaking him wasn't great," said Murray, who has been suffering with a back problem.
"I didn't move very well at the start of the match, but he's a very good grass court player. He's been in the final here and he played well today."
Roddick fared no better as Roger-Vasselin secured a surprise win.
The American has slipped out of the top 30 in the world rankings after an injury-ravaged campaign, but losing to Roger-Vasselin, ranked 67th, on the grass he regards as his favourite surface is a new low.
It was the 29-year-old's 11th defeat in 18 matches this year and raises doubts about his ability to mount a strong challenge at Wimbledon, where he has reached the final three times.
"I've certainly played a lot worse this year," Roddick said.
"I thought I had a chance there in the third set, and honestly I felt like I was going to take that thing once I turned it. It didn't work out that way."
French second seed Tsonga kicked off his title bid with a 6-3, 6-2 win over British wild card Jamie Baker.
There was a shock at the WTA Aegon Classic in Birmingham as top seed Francesca Schiavone lost 7-5, 6-4 to Japan's Miskai Dothe.
It was a day where the seeds fell at Birmingham, number six seed Mona Berthel of Germany losing to Czech Republic's Andrea Hlavackova and USA's number seven seed Christina McHale losing 6-1, 1-6, 7-5 to Elena Vesnina of Russia.