Top seed Murray crashes out at Queen's

(CNN) -- Top seed and reigning champion Andy Murray crashed out of the Aegon Championships at Queen's Club.

The world number four suffered a shock second-round defeat to France's Nicolas Mahut, who won 6-3, 6-7 (4-7), 7-6 (7-1).

Four-time champion Andy Roddick also crashed out at the second round stage, as France's Edouard Roger-Vasselin clinched a shock 6-4, 4-6, 7-5 victory over the seventh seed.

Murray had won the traditional Wimbledon warm-up tournament twice in the last three years, but made a series of errors on his way to defeat against Mahut.

Defeat leaves the Scot without a title since his triumph in Brisbane in January, but Murray insisted there were positives to take from defeat.

"I don't think it went all wrong. It was a very close match but losing serve in the third set after breaking him wasn't great," said Murray, who has been suffering with a back problem.

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"I didn't move very well at the start of the match, but he's a very good grass court player. He's been in the final here and he played well today."

Roddick fared no better as Roger-Vasselin secured a surprise win.

The American has slipped out of the top 30 in the world rankings after an injury-ravaged campaign, but losing to Roger-Vasselin, ranked 67th, on the grass he regards as his favourite surface is a new low.

It was the 29-year-old's 11th defeat in 18 matches this year and raises doubts about his ability to mount a strong challenge at Wimbledon, where he has reached the final three times.

"I've certainly played a lot worse this year," Roddick said.

"I thought I had a chance there in the third set, and honestly I felt like I was going to take that thing once I turned it. It didn't work out that way."

French second seed Tsonga kicked off his title bid with a 6-3, 6-2 win over British wild card Jamie Baker.

There was a shock at the WTA Aegon Classic in Birmingham as top seed Francesca Schiavone lost 7-5, 6-4 to Japan's Miskai Dothe.

It was a day where the seeds fell at Birmingham, number six seed Mona Berthel of Germany losing to Czech Republic's Andrea Hlavackova and USA's number seven seed Christina McHale losing 6-1, 1-6, 7-5 to Elena Vesnina of Russia.