Federer and Murray advance to last 16 of U.S. Open
September 1, 2012 -- Updated 2253 GMT (0653 HKT)
A tired Andy Murray reacts after losing a point in his match against Feliciano Lopez.
- Roger Federer beats Fernando Verdasco in straight sets
- No.1 seed bidding to add to Wimbledon crown in 2012
- Andy Murray battles past Feliciano Lopez in four sets
- Martin Klizan continues surprise run to fourth round
(CNN) -- Roger Federer and Andy Murray took contrasting routes into the last 16 of the U.S. Open Saturday in 32-degree heat and stifling humidity.
Top seed Federer beat 25th seed Fernando Verdasco 6-3 6-4 6-4 to make the fourth round for the 12th successive year.
But Murray nearly fell victim to the conditions against his Spanish opponent Feliciano Lopez, surviving a grueling four-set encounter.
Jim Courier's U.S. Open tips
Can Murray win first tennis grand slam?
The third seed, who beat Federer to win the Olympic title last month, led by two tiebreak sets until wilting in the third.
Up a break, the Briton conceded the advantage and was broken himself three times as the big-hitting left hander Lopez took command.
Murray also struggled to hold in the fourth, but a gritty effort took him to the third tiebreak of the match, which he won 7-4 to progress after over three and a half hours.
He will next face the winner of a later match between American James Blake and 15th-seeded Canadian Milos Raonic.
"This was the first match I had played in this humidity for a while so it was tough," Murray admitted to reporters after his escape.
Meanwhile Federer was never seriously troubled as he earned a clash with either American 23rd seed Mardy Fish or Gilles Simon, the French 16th seed.
Spanish hopes in the absence of the injured Rafael Nadal now rest with consistent Nicolas Almagro, who beat American wildcard Jack Sock in four sets.
Croatian12th seed Marin Cilic beat Japanese 17th seed Kei Nishikori, also in four sets, to earn a last 16 match with unseeded Martin Klizan.
The Slovakian, who accounted for Jo-Wilfried Tsonga in the previous round, beat his doubles partner Jeremy Chardy of France 6-4 6-4 6-4.
Part of complete coverage on
June 30, 2014 -- Updated 1135 GMT (1935 HKT)
When Agnieszka Radwanska refused to look her opponent in the eye after losing at Wimbledon, it raised more than eyebrows.
June 23, 2014 -- Updated 0114 GMT (0914 HKT)
It's 10 years since a teenage Maria Sharapova became the darling of Wimbledon's hallowed Center Court, launching herself as a star.
Rafael Nadal is still the "King of Clay" -- but his crown has slipped a bit, says CNN's Will Edmonds.
May 23, 2014 -- Updated 0746 GMT (1546 HKT)
He's regularly voted France's favorite famous person, but many of the nation's youth have "no idea" about his glorious sporting past
May 5, 2014 -- Updated 2359 GMT (0759 HKT)
The Ukrainian-born, British tennis star loses fight against liver cancer, just a few weeks after revealing that she was battling the disease.
April 29, 2014 -- Updated 1555 GMT (2355 HKT)
Five-time grand slam champion Martina Hingis has followed her mom into a coaching role, setting up a new tennis academy in Barcelona, Spain.
April 16, 2014 -- Updated 1238 GMT (2038 HKT)
It's no easy matter becoming a world class tennis player. It's even harder when everyone (really -- everyone) is calling you the "new Martina Hingis."
April 2, 2014 -- Updated 1420 GMT (2220 HKT)
At the 2009 Australian Open, French men's tennis was the talk of the town.
April 15, 2014 -- Updated 1800 GMT (0200 HKT)
Rafael Nadal may be most at home on a clay tennis court, but he has always found comfort on the sea.
March 21, 2014 -- Updated 1107 GMT (1907 HKT)
Tennis star Venus Williams reveals how she is beating the autoimmune disease that derailed her career.
March 5, 2014 -- Updated 1014 GMT (1814 HKT)
After two decades dedicated to the game, Amelie Mauresmo wants a second life -- one away from tennis.
Almost five years to the day after reducing Roger Federer to tears at the Australian Open, Rafael Nadal shed a few in his own loser's speech.
Today's five most popular stories