(CNN) -- Lionel Messi scored his 300th goal for Barcelona then promptly scored his 301st as the La Liga leaders came from behind to beat Granada 2-1 on Saturday.
The Argentine pounced when Granada keeper Tono could only parry a Cesc Fabregas drive in the 50th minute to level the scores after Nigeria striker Odion Ighalo has given the home side the lead in the 26th minute.
The poacher then turned game-winner 17 minutes from the end, curling a free kick over the wall and past the flailing hand of Toto to register his 36th goal of the Barca's league campaign.
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Lionel Messi breaks goal scoring record
Lionel Messi celebrates after matching Gerd Muller's record of 85 goals in a calendar year, netting in the 16th minute of Barcelona's match against Real Betis. Just nine minutes later the Argentina star passed the German's 1972 milestone.
Lionel Messi's record year
Messi has now scored in the last 14 league games to help the Catalans to a 15-point lead over second-place Atletico Madrid who travel to Valladolid on Sunday.
Neighbors, Real Madrid -- who are third in the table -- also play on Sunday, hosting sixth-place Rayo Vallecano.
In Saturday's other games, Getafe beat relegation-threatened Celta Vigo 3-1 to climb to 11th in the table.
Malaga remain in fourth place after a 1-0 win over struggling Athletic Bilbao -- who have won only once in the last eight league games.
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Over in Serie A, league leaders Juventus lost for the second time this year going down 1-0 at Roma.
The Giallorossi, who sacked coach Zdenek Zeman at the beginning of February, finally ended a miserable league run in 2013 (two points from six games) thanks to a 58th minute goal from Francesco Totti.
Interim manager Aurelio Andreazzoli had said before the game that his team "won't lack commitment" against the Italian champions and so it proved as Roma arrested their freefall down the table and instead climb to seventh above Udinese and Catania -- ahead of their games against Genoa and Bologna on Sunday.
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Juventus stay five points clear at the top, but if Napoli beat Sampdoria on Sunday the gap will close to two points and make the league leaders trip to the Stadio San Paulo on March 1 an even more mouth-watering prospect.
In Serie A's other Saturday fixture, Chievo drew 1-1 with relegation-threatened Palermo.
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The three-time world player of the year, who is shortlisted for a record fourth ballon d'Or in January, passed Muller with three more possible matches to play in 2012.
The 25-year-old crept within one goal of Muller's record with two goals against Athletic Bilbao in a 5-1 victory in December. Click here to see a map of Messi's first 84 goals this year.
However, Messi was injured after coming on as a substitute during a Champions League match against Benfica -- but he made a quick recovery to be fit for the Betis game.
Lionel Messi has enjoyed a stellar 2012. With a hat-trick against Grenada in March, he equaled and broke the all-time goalscoring record for Barcelona in official matches of 232 set by Cesar Rodriguez.
A hat-trick against Malaga in May took Messi to 68 goals for the 2011-12 season, edging him past the record for goals in a European season set by Bayern Munich's Muller in 1972-73.
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