Ebola is extremely infectious but not extremely contagious. It is infectious, because an infinitesimally small amount can cause illness. Laboratory experiments on nonhuman primates suggest that even a single virus may be enough to trigger a fatal infection.
Ebola could be considered moderately contagious, because the virus is not transmitted through the air.
Humans can be infected by other humans if they come in contact with body fluids from an infected person or contaminated objects from infected persons
. Humans can also be exposed to the virus, for example, by butchering infected animals.
While the exact reservoir of Ebola viruses is still unknown, researchers believe the most likely natural hosts are fruit bats
Symptoms of Ebola typically include
: weakness, fever, aches, diarrhea, vomiting and stomach pain. Additional experiences include rash, red eyes, chest pain, throat soreness, difficulty breathing or swallowing and bleeding (including internal).
Typically, symptoms appear 8-10 days after exposure to the virus, but the incubation period can span two to 21 days.
Unprotected health care workers are susceptible to infection because of their close contact with patients during treatment.
Ebola is not transmissible if someone is asymptomatic and usually not after someone has recovered from it. However, the virus has been found in semen for up to three months, and "possibly" is transmitted from contact with that semen, according to the CDC.
Deadly human Ebola outbreaks have been confirmed in the following countries: Democratic Republic of the Congo (DRC), Gabon, South Sudan, Ivory Coast, Uganda, Republic of the Congo (ROC), Guinea, Liberia
and Sierra Leone.
There are five subspecies of the Ebola virus: Zaire ebolavirus (EBOV), Bundibugyo ebolavirus (BDBV), Sudan ebolavirus (SUDV), Taï Forest ebolavirus (TAFV) and Reston ebolavirus (RESTV)
for the CDC's list of known cases and outbreaks.
2014-2016 West Africa Outbreak
(Full historical timeline at bottom)
Cases listed below include confirmed, probable or suspected cases of Ebola as of March-April, 2016 (World Health Organization
Italy - 1 case, 0 deaths
Guinea - 3,811 cases, 2,543 deaths
Liberia - 10,675 cases, 4,809 deaths
Mali - 8 cases, 6 deaths
Nigeria - 20 cases, 8 deaths
Senegal - 1 case, 0 deaths (infection originated in Guinea)
Sierra Leone - 14,124 cases, 3,956 deaths
Spain - 1 case, 0 deaths
United Kingdom - 1 case, 0 deaths
United States - 4 cases, 1 death (two infections originated in the United States, one in Liberia and one in Guinea)
March 25, 2014 -
The CDC issues its initial announcement on an outbreak in Guinea,
and reports of cases in Liberia and Sierra Leone. "In Guinea, a total of 86 suspected cases, including 59 deaths (case fatality ratio: 68.5%), had been reported as of March 24, 2014. Preliminary results from the Pasteur Institute in Lyon, France suggest Zaire ebolavirus as the causative agent."
April 16, 2014 -
The New England Journal of Medicine publishes a report, speculating that the current outbreak's Patient Zero was a two-year-old from Guinea.
The child died on December 6, 2013, followed by his mother, sister and grandmother over the next month.
July 2014 -
Patrick Sawyer, a top government official in the Liberian Ministry of Finance, dies at a local Nigerian hospital. He is the first American to die in what officials are calling "deadliest Ebola outbreak in history."
July 2014 - Nancy Writebol
, an American aid worker in Liberia, tests positive for Ebola. According to Samaritan's Purse, Writebol is infected while treating Ebola patients in Liberia.
July 26, 2014 - Kent Brantly
, medical director for Samaritan Purse's Ebola Consolidated Case Management Center in Liberia, is infected with the virus. According to Samaritan's Purse, Brantly is infected while treating Ebola patients.
July 30, 2014 - The Peace Corps announces
it is removing its volunteers from Liberia, Sierra Leone and Guinea.
July 31, 2014 - CDC raises its warning to Level 3
. It warns US residents to avoid "nonessential travel" to Sierra Leone, Guinea, and Liberia.
August 2, 2014 -
A specially equipped medical plane carrying Ebola patient Dr. Kent Brantly lands at Dobbins Air Reserve Base in Marietta, Georgia. He is then driven by ambulance to Emory University Hospital in Atlanta.
August 4, 2014 -
CNN reports that three top secret, experimental vials of the drug, "ZMapp," were flown into Liberia last week
in a last-ditch effort to save Brantly and Writebol, according to a source familiar with details of the treatment. Doctors report "significant improvement."
August 6, 2014 - Nancy Writebol arrives at Emory in Atlanta for treatment.
August 8, 2014 - Experts at the World Health Organization declare the Ebola epidemic ravaging West Africa an international health emergency that requires a coordinated global approach, describing it as the worst outbreak in the four-decade history of tracking the disease.
August 19, 2014 - Liberia's President Ellen Johnson Sirleaf declares a nationwide curfew beginning August 20 and orders two communities to be completely quarantined, with no movement in or out of the areas.
August 21, 2014 -
Dr. Kent Brantly is discharged from Emory University Hospital. It is also announced that Nancy Writebol had been released on Tuesday, August 19. The releases come after Emory staff are confident Brantly and Writebol pose "no public health threat."
September 6, 2014 - The government of Sierra Leone announces plans for a nationwide lockdown from September 19-21, in order to stop the spread of Ebola. The lockdown is being billed as a predominantly social campaign rather than a medical one, in which volunteers will go door-to-door to talk to people.
September 16, 2014 -
President Barack Obama calls the efforts to combat the Ebola outbreak centered in West Africa "the largest international response in the history of the CDC." Speaking from the CDC headquarters in Atlanta, Obama adds that "faced with this outbreak, the world is looking to" the United States to lead international efforts to combat the virus. He says the United States is ready to take on that leadership role.
September 30, 2014 -
Dr. Thomas Frieden, director of the CDC, announces the first diagnosed case of Ebola in the United States.
The person has been hospitalized and isolated at Texas Health Presbyterian Hospital in Dallas since September 28.
October 1, 2014 -
Liberian government officials release the name of the first diagnosed case of Ebola in the United States: Thomas Eric Duncan
October 6, 2014 -
A nurse's assistant in Spain becomes the first person known to have contracted Ebola outside Africa in the current outbreak. The woman helped treat two Spanish missionaries, both of whom had contracted Ebola in West Africa, one in Liberia and the other in Sierra Leone. Both died after returning to Spain. On October 19, Spain's Special Ebola Committee says that nurse's aide Teresa Romero Ramos is considered free of the Ebola virus.
October 6, 2014 -
NBC freelance cameraman Ashoka Mukpo arrives at Nebraska Medical Center for treatment after contracting Ebola in Liberia. On October 21, the hospital says that Mukpo no longer has the Ebola virus in his bloodstream and will be allowed to leave.
October 8, 2014 - Thomas Eric Duncan dies of Ebola in Dallas.
October 11, 2014 -
Nina Pham, a Dallas nurse who cared for the now-deceased Ebola patient Thomas Eric Duncan, tests positive for Ebola during a preliminary blood test.
She is the first person to contract Ebola on American soil.
October 15, 2014 -
Amber Vinson, a second Dallas nurse who also cared for Thomas Eric Duncan, is diagnosed with Ebola. Authorities say Vinson flew on a commercial jet from Cleveland to Dallas days before testing positive for Ebola.
October 20, 2014 -
Under fire in the wake of Ebola cases involving two Dallas nurses, the CDC issues updated Ebola guidelines
that stress the importance of more training and supervision, and recommend that no skin be exposed when workers are wearing personal protective equipment, or PPE.
October 23, 2014 -
Craig Spencer, a 33 year-old doctor who recently returned from Guinea has tested positive for Ebola
-- the first case of the deadly virus in New York City and the fourth diagnosed in the United States.
October 24, 2014 -
The National Institutes of Health announces one of the Dallas nurses, Nina Pham, has been declared free of the Ebola virus. Doctors at Emory University Hospital say tests no longer detect the virus in the blood of the other nurse, Amber Vinson. Pham is released
from a Maryland hospital on October 24, and Vinson is released
from an Atlanta hospital on October 28.
October 24, 2014 - In response to the New York Ebola case, the governors of New York and New Jersey announce that their states were stepping up airport screening beyond federal requirements for travelers from West Africa. The new protocol mandates a quarantine for any individual, including medical personnel, who has had direct contact with individuals infected with Ebola while in Liberia, Sierra Leone, or Guinea. The policy allows the states to determine hospitalization or quarantine for up to 21 days for other travelers from affected countries.
November 5, 2014 - Nurse's aide Maria Teresa Romero Ramos, believed to be the first person to contract Ebola outside of Africa, is released from the hospital in Madrid, Spain.
November 11, 2014 -
Dr. Craig Spencer, the first person to test positive for Ebola in New York City, is released from Bellevue Hospital. With Spencer free of the virus, all US patients who had Ebola have recovered.
November 15, 2014 - Dr. Martin Salia, who became infected with Ebola while treating patients in Sierra Leone, arrives at Nebraska Medical Center in Omaha. Salia, a native of Sierra Leone, is a legal permanent resident of the United States married to a US citizen.
November 17, 2014 - Dr. Salia dies at Nebraska Medical Center.
November 21, 2014 - The World Health Organization declares an end to the Ebola outbreak in the Democratic Republic of Congo. A total of 66 cases and 49 deaths were recorded.
December 24, 2014 -
The CDC announces that a technician will be monitored for three weeks after possibly being exposed to the Ebola virus at one of the agency's Atlanta labs. The agency reports a small amount of material which may have contained the live virus had been mistakenly transferred from one lab to another.
December 2014 -
American doctor Ian Crozier, who had been declared free of Ebola and released from Emory University Hospital in October 2014, finds the virus in his left eye
. He had contacted the disease while working in Sierra Leone. Not at risk of spreading the disease, Dr. Crozier is treated and on his way to Liberia by early April 2015.
January 18, 2015 -
Mali is declared Ebola free after no new cases in 42 days.
February 22, 2015 -
Liberia reopens its land border crossings shut down during the Ebola outbreak, and Liberian President Ellen Johnson Sirleaf also lifts a nationwide curfew imposed in August to help combat the virus.
May 9, 2015 -
The World Health Organization declares an end to the Ebola outbreak in Liberia. More than 4,000 died.
November 2015 -
Liberia's health ministry says three new, confirmed cases
of Ebola have emerged in the country.
December 29, 2015 -
The World Health Organization declares Guinea is free of Ebola
after 42 days pass since the last person confirmed to have the virus was tested negative for a second time.
January 14, 2016 - A statement is released by the UN stating that "For the first time since this devastating outbreak began, all known chains of transmission of Ebola in West Africa have been stopped and no new cases have been reported since the end of November."
January 15, 2016 - A new case of Ebola - in Sierra Leone - in which the patient died - is confirmed by WHO and the CDC.
April 1, 2016 - The World Health Organization announces via Tweet that a new case of Ebola has been reported in Liberia.
The organization declares that sporadic flare-ups are expected even as the major health emergency is over.
*Includes outbreaks resulting in more than 100 deaths or special cases.
1976 - First recognition of the EBOV disease is in Zaire (now Democratic Republic of the Congo). The outbreak has 318 reported human cases, leading to 280 deaths. An SUDV outbreak also occurs in Sudan (now South Sudan), which incurs 284 cases and 151 deaths.
1990 - In Texas and Virginia quarantine facilities, four humans develop Ebola antibodies after contact with monkeys imported from the Philippines. None of the humans has symptoms.
1995 - An outbreak in Democratic Republic of the Congo (formerly Zaire) leads to 315 reported cases and at least 250 deaths.
2000-2001 - A Ugandan outbreak (SUDV) results in 425 human cases and 224 deaths.
2001-2002 - An EBOV outbreak occurs on the border of Gabon and Republic of the Congo (ROC), which results in 53 deaths on the Gabon side and at least 43 deaths on the Republic of the Congo side.
December 2002-April 2003 - An EBOV outbreak in Republic of the Congo results in 143 reported cases and 128 deaths.
2007 - An EBOV outbreak occurs in the Democratic Republic of the Congo (DRC), 187 of the 264 cases reported result in death. In late 2007, an outbreak in Uganda leads to 37 deaths. 149 cases were reported.
November 2008 -
The Ebola-Reston virus (RESTV) is detected in five humans in the Philippines.
They are workers on a pig farm and slaughterhouse and suffer no symptoms.
August 26, 2014 - The Ministry of Health in the Democratic Republic of the Congo notifies the World Health Organization of an Ebola outbreak in the country. It is the seventh outbreak in the country since 1976, when the virus was first identified near the Ebola river. The outbreak is not related to the ongoing outbreak in Guinea, Liberia, Nigeria and Sierra Leone.
July 31, 2015 -
The CDC announces that a newly developed Ebola vaccine
is "highly effective" and could help prevent its spread in the current and future outbreaks.