Skip to main content
Part of complete coverage on

Time-lapse video reveals secret life of an embryo, helps women conceive

By Kieron Monks and Samantha Bresnahan, for CNN
June 16, 2014 -- Updated 1106 GMT (1906 HKT)
  • Embryoscope gives time-lapse images of IVF embryos
  • It gives valuable insight into embryo development
  • The most viable embryos can be chosen for implantation
  • The technology is improving IVF success rates

Vital Signs is a monthly program bringing viewers health stories from around the world.

(CNN) -- It is estimated that around one in four couples around the world have trouble conceiving. For a small proportion of them, In Vitro Fertilisation (IVF) is a technology that can restore the dream of parenthood.

IVF is the fertilization of an egg by sperm outside the body, where it is cultivated in a lab environment, and if an embryo results it is implanted into the mother's womb. Now the chances of IVF treatment being successful are being boosted by a machine called the Embryoscope.

A record number of babies are being born through IVF -- with over 60,000 IVF babies born in the United States alone in 2012. But since the inception of IVF in the 1970s, monitoring embryos has been a difficulty. In order to examine them, the embryologist must remove them from the safe environment of the incubator and expose them to environmental hazards such as temperature changes and contaminants.

Read: Return of the 'White Plague'?

Embryos are removed and examined just once a day, which limits the information available to embryologists, as well as the chances of picking the embryo with the best chance of delivering a viable pregnancy.

Embryo development

I think this is the most exciting breakthrough since IVF started.
Dr. Simon Fishel, managing director CARE Fertility

But these longstanding issues are being addressed by the Embryoscope. The device combines an incubator that maintains perfect conditions, with a tiny camera that takes photos every 10-15 minutes -- creating a time-lapse video of the embryo's development. This removes the need to expose the embryo to the outside atmosphere, and provides embryologists with far greater information with which to make decisions.

"I think this is the most exciting breakthrough since IVF started," says Dr. Simon Fishel, managing director of the UK's CARE Fertility, responsible for the first Embryoscope baby born in the UK, in 2012 (as well as the first ever IVF baby back in 1978).

"The information that we are gathering with the Embryoscope with the time-lapse is far superior," he says. "We have much, much more information on which to base the crucial decision as to which embryo is the one to transfer back to the patient."

Embryos that show early abnormalities can be immediately ruled out, and learning algorithms have been created that recognize positive or negative patterns at key development points thereafter -- meaning patients can be implanted with embryos that have an optimal chance of success.

"We have a predictive scale (for evaluating) the likelihood of an embryo to give the best chance of a live birth," says Fishel. "It's a complex procedure and it uses very complex technology and some mathematics. But using this whole process, it really changes the way the embryologists work in the lab. And I think it's changing the face of how we do IVF, in fact."

How far has IVF treatment come?
How does IVF work?

Improving the odds

The extra information is particularly beneficial for patients with the lowest chances of pregnancy -- such as older women, or those with reduced egg counts. CARE estimates its use of the Embryoscope and algorithms broadly increases the chance of a pregnancy by around 20%.

"The images also allow you a higher level of assurance to pick an embryo with the highest chance of being genetically normal," says Dr. Jason Barritt, lab director at the ART Reproductive Center, in California.

The technology can also provide insights into early-stage development beyond the need to conceive. A recent Spanish study conducted with an Embryoscope showed differences in growth patterns between male and female embryos, which could potentially allow gender to be more rapidly determined.

Use of the Embryoscope has spread to IVF facilities around the world, but some barriers remain: the vast amount of extra data requires greater resources for analysis, and the technology itself is expensive. But much of IVF is about trying to beat the odds, and as technology progresses, so do the chances of parenthood for couples who can't conceive naturally.

Read: Hunting down 'fiery serpent' disease

Read: Carpenter cuts off his fingers, makes new ones

Read: From toilet to tap: Drinking recycled waste water

Part of complete coverage on
April 2, 2014 -- Updated 0958 GMT (1758 HKT)
A 3-D printed exoskeleton is helping children with a rare neuromuscular disease.
March 19, 2014 -- Updated 1109 GMT (1909 HKT)
mohammad daniel project daniel
Artificial limbs made by 3-D printing are changing the lives of amputees in Sudan.
April 24, 2014 -- Updated 1002 GMT (1802 HKT)
A device for extracting water from air is being used by the military -- could it help developing countries too?
May 23, 2014 -- Updated 0931 GMT (1731 HKT)
Air-cleaning pavillion to be launched at the 2015 Milan Expo
Air pollution is now the biggest global environmental killer, but these high-tech solutions could save lives.
May 28, 2014 -- Updated 1718 GMT (0118 HKT)
TB is growing increasingly drug resistant -- and it's becoming a global problem.
August 22, 2014 -- Updated 1948 GMT (0348 HKT)
A picture taken on June 28, 2014 shows a member of Doctors Without Borders (MSF) putting on protective gear at the isolation ward of the Donka Hospital in Conakry, where people infected with the Ebola virus are being treated. The World Health Organization has warned that Ebola could spread beyond hard-hit Guinea, Liberia and Sierra Leone to neighbouring nations, but insisted that travel bans were not the answer.
Nearly 40 years after Ebola was discovered, there is no cure. But could experimental vaccines protect people?
May 9, 2014 -- Updated 1027 GMT (1827 HKT)
A Southern Sudanese man uses a pipe filter to protect himself from Guinea worm disease while drinking water from a potentially infected source. The pipe filter strains out the water fleas that can contain Guinea worm larvae.
Guinea worm disease once infected millions -- now it's almost eradicated. But can we catch the final cases?
April 17, 2014 -- Updated 1544 GMT (2344 HKT)
3d printed eye
Scientists are bioprinting human body parts from ears to bones. Here are some the most impressive advances.
April 14, 2014 -- Updated 1954 GMT (0354 HKT)
robohand metal hand
A South African carpenter lost his fingers in an accident -- now he's making mechanical fingers and hands for others.
May 16, 2014 -- Updated 0932 GMT (1732 HKT)
care o bot
Robot carers are helping elderly people, watching their health and keeping them company.
May 1, 2014 -- Updated 1446 GMT (2246 HKT)
A woman fills in a glass of water on April 27, 2014 in Paris. AFP PHOTO / FRANCK FIFE
Half the world is facing water shortages, so is it time for us all to start drinking recycled sewage?
vital signs logo
Vital Signs is a monthly program bringing viewers health stories from around the world.