One survey suggests ISIS lost nearly a quarter of its territory in Iraq and Syria last year alone, and more than a third since its peak.
Its finances have taken a hit, according to the US-led coalition and 180 "senior" leaders have been taken out by 17,000 airstrikes.
The group's slickly produced, often gruesome, media output has been massively reduced, but, according to one analyst, it's of higher quality than before.
Here's ISIS state of play before Donald Trump takes office.
ISIS' caliphate shrinks in 2016
ISIS is losing ground across its self-proclaimed caliphate, according to a new report.
Global intelligence and analysis firm IHS Conflict Monitor, which uses open-source intelligence including social media and on-the-ground sources, estimates that ISIS lost 17,600 square kilometers (6,800 square miles) of the land it held in Iraq and Syria over 2016. ISIS' caliphate in the two countries shrunk by 23% over the course of the year, according to a survey and map released by IHS. The group lost 34% in the same region compared to January 2015.
The US-led coalition say ISIS has lost 27% of its territory in Syria -- and 61% in Iraq -- from its peak.
De facto capital remains in Syria
In addition to ISIS' de facto capital of Raqqa, the militant group retains patches of land not far from Homs and around the ancient city of Palmyra -- control of which it regained from the Syrian regime late last year. It also has a presence in the countryside around the eastern city of Deir Ezzor.
IHS reported spikes in territory lost by ISIS when the US-backed Syrian Democratic Forces, or SDF, took control of the strategic city of Ash Shaddadi in March, moved on to Manbij in May, and in mid-October when Euphrates Shield, Turkey's ground operation against ISIS in Syria, retook the symbolically significant town of Dabiq.
ISIS fights off advances on Mosul
ISIS's presence has been felt in Samarra, and also recently in attacks in Baghdad
But the group is mostly confined in urban centers to Mosul, where it's on the cusp of losing the east bank of the city. That would leave it with just the west side, although some estimates suggest the battle for the group's final stronghold in Iraq could continue to drag on into March.
IHS points to a spike in territory lost by ISIS in May when Iraqi security forces kicked militants out of Rutba and western Anbar, and another in October when the operation to retake Mosul began.
US Air Force Col. John L. Dorrian, spokesman for the US-led operation against ISIS, says the group has lost Ramadi, Falluja, Hiit, Qayyara and Sharqat.
Beyond Iraq and Syria
Late last year, ISIS also lost control
of Sirte, its final stronghold in Libya, but continued to retain perhaps hundreds of fighters in the country.
This could pose a threat to the already volatile security of Libya's cities and also perhaps serve as a platform for plotting attacks in nearby Europe.
Meanwhile in Afghanistan, in the east of the country, an initial wave of US airstrikes backing an Afghan army campaign pushed the militant group back.
But ISIS has proven to be a resilient presence in a handful of provinces, attracting extremists alienated by the Taliban's superannuated insurgency. The suicide bomber that killed dozens late last year at a Shia mosque in Kabul
claimed affiliation with ISIS.
Finances have been hit hard
According to Dorrian, airstrikes against ISIS' infrastructure and cash storage facilities have reduced the group's revenue "or cost them anywhere from $4.5-6.5 million" per month.
ISIS' loss of territory has also reduced the number of civilians it can tax, Dorrian said, and the 600 airstrikes against oil facilities and oil truck shipments hasn't helped its finances either.
Pay to ISIS fighters has been disrupted as well as death benefits for suicide bombers.
ISIS-inspired global attacks
Since declaring its caliphate in June 2014, the self-styled Islamic State has conducted or inspired more than 140 terrorist attacks in 29 countries other than Iraq and Syria.
Those attacks have killed at least 2,043 people and injured thousands more, according to a running CNN tally
ISIS' direct level of involvement in these attacks varies.