HIV/AIDS Fast Facts

(CNN)Here's a look at the origins and global response to HIV and AIDS.

Facts:
HIV stands for human immunodeficiency virus.
AIDS stands for acquired immunodeficiency syndrome.
    HIV/AIDS is spread through sexual contact with an infected person, sharing needles with an infected person, through transfusions of infected blood or through an infected mother.
    People infected with HIV go through three stages of infection:
    1. Acute infection, or acute retroviral syndrome, which can produce flu-like symptoms in the first month after infection.
    2. Clinical latency, or asymptomatic HIV infection, in which HIV reproduces at lower levels.
    3. AIDS, in which the amount of CD4 cells fall below 200 cells per cubic millimeter of blood (as opposed to the normal level of 500-1,500).
    HIV-1 and HIV-2 can both cause AIDS. HIV-1 is the most common human immunodeficiency virus; HIV-2 is found mostly in western Africa.
    Antiretroviral therapy (ART) involves taking a cocktail of HIV medications used to treat the virus. In 1987, Azidothymidine (AZT) became the first FDA-approved drug used to attempt to treat HIV/AIDS.
    Statistics (from UNAIDS) as of August 2018:
    36.9 million - Average number of people living with HIV/AIDS worldwide in 2017.
    9.4 million - Average number of people living with HIV globally that are unaware of their HIV-positive status in 2017.
    180,000 - New infections in children worldwide in 2017.
    1.8 million - New infections worldwide in 2017.
    940,000 - AIDS-related deaths worldwide in 2017.
    More than half of all people living with HIV globally are in sub-Saharan Africa.
    Sub-Saharan Africa is comprised of the following countries: Angola, Benin, Botswana, Burkina Faso, Burundi, Cameroon, Cape Verde, Central African Republic, Chad, Comoros, Democratic Republic of the Congo, Ivory Coast, Djibouti, Equatorial Guinea, Eritrea, Ethiopia, Gabon, The Gambia, Ghana, Guinea, Guinea-Bissau, Kenya, Lesotho, Liberia, Madagascar, Malawi, Mali, Mauritania, Mauritius, Mozambique, Namibia, Niger, Nigeria, Republic of the Congo, Rwanda, Sao Tome and Principe, Senegal, Seychelles, Sierra Leone, Somalia, South Africa, Sudan, South Sudan, Swaziland, Tanzania, Togo, Uganda, Zambia and Zimbabwe.
    Timeline:
    1981 - The Centers for Disease Control and Prevention (CDC) publish the first reports of men in Los Angeles, New York and San Francisco who were previously healthy and are suffering from rare forms of cancer and pneumonia, accompanied by "opportunistic infections."
    1983 - French and American researchers determine that AIDS is caused by HIV.
    1985 - Blood tests to detect HIV are developed.
    December 1, 1988 - First World AIDS Day.
    1999 - Researchers in the United States find evidence that HIV-1 most likely originated in a population of chimpanzees in West Africa. The virus appears to have been transmitted to people who hunted, butchered and consumed the chimpanzees for food.
    January 29, 2003 - In his State of the Union speech, US President George W. Bush promises to dramatically increase funding to fight HIV/AIDS in Africa.
    May 27, 2003 - Bush signs H.R. 1298, the US Leadership Against HIV/AIDS, Tuberculosis and Malaria Act of 2003, also known as PEPFAR (US President's Emergency Plan for AIDS Relief), that provides $15 billion over the next five years to fight HIV/AIDS, tuberculosis and malaria abroad, particularly in Africa.
    July 30, 2008 - H.R. 5501, The Tom Lantos and Henry J. Hyde United States Global Leadership Against HIV/AIDS, Tuberculosis, and Malaria Reauthorization Act of 2008, becomes law and authorizes up to $48 billion to combat global HIV/AIDS, tuberculosis and malaria. Through 2013, PEPFAR plans to work in partnership with host nations to support treatment for at least four million people, prevention of 12 million new infections and care for 12 million people.
    October 2011 - In his book, "The Origins of AIDS," Dr. Jacques Pepin traces the emergence and subsequent development of HIV/AIDS to suggest that initial AIDS outbreaks began earlier than previously believed.
    July 24, 2012 - Doctors announce during the 19th International AIDS Conference that Timothy Ray Brown, known as the Berlin patient, has been "cured" of HIV. Brown, diagnosed with leukemia, underwent a bone marrow transplant in 2007 using marrow from a donor with an HIV-resistant mutation. He no longer has detectable HIV.
    March 3, 2013 - Researchers announce that a baby born infected with HIV has been "functionally cured." The child, born in Mississippi, was given high doses of antiretroviral drugs within 30 hours of being born. Two years later, doctors were unable to detect evidence of HIV in the child's blood.
    June 18, 2013 - Marking the 10th anniversary of PEPFAR, Secretary of State John Kerry announces that the millionth child has been born HIV-free due to prevention of mother-to-child transmission programs (PMTCT).
    March 14, 2014 - The CDC reports on a case of likely female-to-female HIV transmission. Unlike previous announcements of other cases involving female-to-female transmission, this case excludes additional risk factors for HIV transmission.
    July 10, 2014 - A Mississippi baby, declared to be "functionally cured" of HIV in 2013, now has detectable levels of the virus in her blood, 27 months after being taken off antiretroviral drugs, according to scientists involved with her case.
    July 24, 2017 - A 9-year-old child from South Africa is reported to have been in remission for over eight years without treatment, according to Dr. Avy Violari, who spoke at the 9th International AIDS Society Conference on HIV Science in Paris.