They wrote books that revolutionized people's view of society; made scientific discoveries that transformed medicine as we know it; and brought about laws that shook up the establishment.
In celebration of International Women's Day on March 8,
Leading Women takes a look at just seven of the many females throughout history who changed the world for the betterment of all.
The American author's best-selling 1852 novel "Uncle Tom's Cabin" helped popularize the anti-slavery movement.
Legend has it
Abraham Lincoln greeted Beecher Stowe at the White House by saying: "So you're the little woman who wrote the book that started this great war," in reference to the civil war.
Her novel followed the life of black slave Uncle Tom, and was the second best-selling book of the 19th century after the Bible.
Emmeline Pankhurst, led women's right to vote movement
British suffragette Emmeline Pankhurst founded the Women's Social and Political Union (WSPU), a group known for extreme forms of protest such as chaining themselves to railings and going on hunger strikes.
"We are here, not because we are law-breakers; we are here in our efforts to become law-makers," she said during a court trail in 1908.
Sadly Pankhurst never lived to see her dream become reality, dying three weeks before a law was passed giving women equal voting rights with men.
Anne Frank, writer of Holocaust diary
"What is done cannot be undone, but one can prevent it happening again" -- Anne Frank's "Diary of a Young Girl."
The wisdom and wit of 13-year-old Jewish schoolgirl Anne Frank, written while hiding in Amsterdam during the Second World War, is one of the most widely-read books in the world with over 30 million copies
Her story of life under German occupation is a powerful record that has been translated into 67 languages and adapted for both film and theater, with her home itself turned into a museum.
Frank died in the Bergen-Belsen concentration camp in 1945, just weeks before it was liberated.
Simone de Beauvoir, philosopher and writer of "The Second Sex"
French existentialist philosopher Simone de Beauvoir's 1949 book "The Second Sex" became a landmark feminist work.
It analyzed the treatment and perception of women throughout history, and was deemed so controversial that the Vatican put in on the Index of Prohibited books.
"All oppression creates a state of war; this is no exception," said De Beauvoir, who along with partner Jean Paul Sartre was one of the most influential thinkers of the 20th century.
Rosalind Franklin, scientist helped understanding of DNA