Meldonium: the drug that got Maria Sharapova suspended from tennis

Updated 6:46 AM EST, Wed March 9, 2016
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Story highlights

Meldonium protects heart tissue

It was added to the list of anti-doping drugs in January

The normal course of treatment is days or weeks

(CNN) —  

Suspended Russian tennis champ Maria Sharapova admits she made a “huge mistake” by taking a banned performance-enhancing drug called meldonium. But what is it? For what medical reasons would an athlete take it? And why is it banned?

The drug, known as meldonium or mildronate, is not approved by the Food and Drug Administration in the United States, but it is prescribed elsewhere to help protect heart tissue by regulating metabolism. It has also been used by neurological clinics to treat patients who have asthenia – an abnormal lack of energy.

READ: So what next for Sharapova?

The substance had only recently come to the attention of the World Anti-Doping Agency, which started monitoring the use of the drug by athletes in 2015 and banned it outright beginning this year.

Sharapova’s drug sample was collected on January 26.

How would meldonium help an athlete?

The drug “demonstrates an increase in endurance performance of athletes, improved rehabilitation after exercise, protection against stress, and enhanced activations of central nervous system functions,” according to a study last year in the journal Drug Testing and Analysis.

Side effects can include allergic reactions, indigestion, increased heart rate and changes in blood pressure, according to the drug’s prescribing label.

Meldonium is among a class of banned drugs called hormone and metabolic modulators that account for about 5% of doping in sports, according to a 2014 study by the international doping agency.

READ: The human misery of sport doping

Banned drug modulators have been used by cyclists, weightlifters, boxers, wrestlers, skiers and other athletes from more than 25 countries including Russia, Poland, Columbia, Belgium and Germany.

The agency said it added meldonium to its list of modulators “because of evidence of its use by athletes with the intention of enhancing performance.”

Why was Sharapova taking it?

In an email to CNN, Sharapova’s attorney said the tennis player took 500mg of mildronate on a regular basis for 10 years and that she was unaware the drug had another name and was banned.

Sharapova was first prescribed the drug in early 2006, according to her attorney, after tests revealed that “she has some immune deficiency, abnormal EKG results, diabetes indicators, low magnesium and asthenia.”

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The manufacturer of mildronate, Grindex pharmaceuticals, says the drug is “widely used for the treatment of different heart and vascular diseases.” It notes the substance is also used to improve “work capacity” in healthy people who are overloaded physically or mentally or who are in a rehabilitation period.

READ: Opinion: Why sport should allow doping