Several thousand Uganda fans are estimated to have traveled to Gabon for their country's first AFCON appearance for almost 40 years.
Under the guidance of Serbian coach Milutin Sredojevic (R) and his staff, these players have already made history but got their AFCON 2017 campaign underway with a 1-0 defeat to powerhouse Ghana.
Andre Ayew's penalty was all that separated the sides following Isaac Isinde's foul on Asamoah Gyan inside the box.
None of the current Uganda squad was even born when the country last competed in an AFCON, a tournament which culminated in a 2-0 defeat in the final against Tuesday's opponents Ghana.
Ghana's forward Gyan (R) will be looking to score his 50th international goal and reach 100 caps at AFCON 2017.
Mali supporters were already filling the stadium as they awaited the start of their match against Egypt.
Mali went into the match as underdog and Egypt's Pharaohs are hoping to win their eighth Africa Cup of Nations.