Buffy and Angel, 'Buffy the Vampire Slayer' – It became clear this romance was doomed as soon as it turned out that a night of passion with Buffy (Sarah Michelle Gellar) would turn vampire-with-a-soul Angel (David Boreanaz) back into his evil self, Angelus. Buffy ended up with another vamp; Spike and Angel ended up with a spinoff. Here's a look at other TV couples we've cheered on.
Brenda and Dylan, 'Beverly Hills 90210' – Dylan McKay and Brenda Walsh (Luke Perry and Shannen Doherty) were the "It" couple on "Beverly Hills 90210," helping the show become one of Fox's first hits. But there was friction between Doherty and other cast members, and that was it for romance
Nick and Jess, 'New Girl' – When Zooey Deschanel's Jess moved in with three guys in Fox's hit sitcom "New Girl," you knew she would end up with one of them. It soon became clear that she had a connection with Nick (Jake Johnson), but fans wondered how long before they would become a couple.
Luke and Laura, 'General Hospital' – Soaps never saw anything like Luke (Anthony Geary) and Laura (Genie Francis) and haven't since. The couple's wedding in 1981 broke ratings records, and "General Hospital" has brought them back off and on in the years since.