Story highlights
The common sexually transmitted virus can cause cancer in many areas of the body
An HPV vaccine is available, but many men haven't gotten it or are too old to get it
About one in nine American men is infected with the oral form of human papillomavirus (HPV), according to a new study published in the journal Annals of Internal Medicine. Nationwide, rates for oral HPV infections are 11.5% of men and 3.2% of women: 11 million men, compared with 3.2 million women, the researchers estimated.
An infection with this common virus, which is transmitted through intimate skin-to-skin contact, can cause cancer in several areas of the body, including the throat, anus, penis and vagina. Nearly all men and women will become infected with at least one type of HPV, a group of 150 related viruses, at some point in their lives, according to the US Centers for Disease Control and Prevention.
Previous studies have shown that men have higher rates of overall HPV infections than women. The research published Monday reveals the higher rates of oral HPV infections occurring among men, said Ashish A. Deshmukh, senior author of the study and an assistant professor at the University of Florida’s College of Public Health and Health Professions.
“One suspects that the HPV persists longer (means doesn’t clear easily) among men and that might be causing increased prevalence,” Deshmukh noted in an email.
“It is also possible that men acquire oral HPV more readily than women,” he said. Yet another possibility could be that, after a first infection, women develop greater resistance to subsequent infections. “Further research is needed to understand the reason behind this,” Deshmukh added.
A warning to men
Annually, an average of 38,793 cases of HPV-related cancer – 59% of them in women and 41% in men – were diagnosed in the United States between 2008 and 2012.
Yet, in each year within that time span, a type of head and neck cancer called oropharyngeal squamous cell carcinoma was far more likely to strike men: 12,638 cases diagnosed in men each year, compared with just 3,100 cases in women.
It is the most common of all the HPV-related cancers, and its incidence among men (7.8 per 100,000) now surpasses incidence rates of cervical cancer among women (7.4 per 100,000). Cervical cancer is known to be caused by HPV.
An HPV vaccine is available for both men and women and can protect against infection, yet many men are over the eligibility age of 26, and younger men have low vaccination rates. The CDC recommends the vaccination for adolescents.
Deshmukh and a team of researchers used data from the National Health and Nutrition Examination Survey to look at oral HPV infection rates in addition to how many men and women have both oral and genital HPV.
This CDC survey monitors the health and nutritional status of the nation’s population. Participants between the ages of 18 and 69 were given a physical examination, which included laboratory tests for 37 HPV types, followed by an interview.
All told, about 11.5% of study participants had an oral HPV infection.
Overall, the prevalence of all high-risk and low-risk HPV types was consistently higher in men. High-risk HPV infections affected 7.3% of men overall and 1.4% of women overall, while the highest number of high-risk cases were found in the 50- to 54-year-old group for both men and women, the researchers found.
HPV 16, the most common type of high-risk HPV and known to contribute to head and neck cancers, was six times higher among men (1.8%) than women (0.3%). It was most prevalent in men 50 to 69 years old, the team said.
“The rates of oropharyngeal cancer among men have risen more than 300 percent in the past 40 years making oropharyngeal cancer most common HPV-related cancer in the United States,” Deshmukh wrote in an email.
“In contrast, the rates of oropharyngeal cancer among women have declined.”
High-risk groups
Men who have had multiple sex partners, men who reported having sex with men, and men with genital HPV infections were found to have the highest rates