The first of many. A 17-year-old Williams beats Martina Hingis at the 1999 US Open in straight sets to win her first major title.
Conquering clay. Serena beats sister Venus at Roland Garros 7-5 6-3 in 2002 to claim her second grand slam at the French Open.
A few weeks later, Serena makes it a hattrick of grand slams with victory over Venus at the Wimbledon final in July 2002.
Serena comes out on top after another final with Venus, beating her sister in straight sets to win her second US Open title in 2002.
A grand slam of grand slams -- the first "Serena Slam." Serena wins a first Australian Open title -- and a fourth major on the trot -- by beating Venus in three sets in 2003.
Serena wins the 2003 Wimbledon final 4-6 6-4 6-2 against sister Venus to defend her crown.
A second Australian Open title for Serena and a seventh grand slam after a 2-6 6-3 6-0 victory over compatriot Lindsay Davenport in the 2005 Melbourne final.
Victory over Maria Sharapova in the 2007 final secures a third Australian Open title for Serena.
Serena on Times Square with the US Open trophy, a title she won without dropping a set at the 2008 tournament.
Ten years of grand slam success and a 10th major for Serena as she beats Dinara Safina in straight sets at the Australian Open final in 2009.
Another victory over sister Venus in a Wimbledon final and Serena clinches her third title at SW19 in 2009.
Serena poses with the Daphne Akhurst Trophy in 2010, her fifth Australian Open title.
A two-year wait, but Serena notches a 14th major with yet more success at Wimbledon. She beats Poland's Agnieszka Radwanska 6-1 5-7 6-2 in the 2010 final to level with sister Venus with five Wimbledon titles.
Wimbledon 2012 was Williams' first grand slam since spending almost a year out of action between summer 2010 and 2011 with a leg injury and subsequent pulmonary embolism.
Thirteen years after her first US Open title, Serena grabs a fourth by beating world No.1 Victoria Azarenka in the final
Serena with the Coupe Suzanne Lenglen trophy in front of the Eiffel Tower after victory over Sharapova in the 2013 final.
Another US Open for Serena, beating Azarenka in the 2013 final for the second successive year.
Victory at the US Open in 2014 moves Williams to joint-fourth in the all-time list of major winners, alongside Martina Navratilova and Chris Evert.
Another fine start to a year as Williams wins the 2015 Australian Open -- once again beating Sharapova in a major final.
A second grand slam of the year and a third French Open after a 6-3 6-7 6-2 win over Czech Republic's Lucie Safarova in 2015.
A third major title of the year thanks to a straight-sets win over Spain's Garbine Muguruza in the 2015 Wimbledon final. But there was to be no "Serena Slam'"of four majors in the same calendar year.
A seventh Wimbledon title for the then world No.1 and now equal with Steffi Graf's Open era record of major titles. "This court definitely feels like home," says Williams after her straight sets win over Angelique Kerber in 2016.
At the start of 2017, sister Venus is beaten in straight sets as a seventh Australian Open is secured and an Open-era record 23rd Grand Slam singles title won. Later we would find out she won while pregnant with her first child.