CNN  — 

With the US Food and Drug Administration issuing an emergency use authorization for the first US coronavirus vaccine Friday night, state and federal officials are making plans to give people their first shots and convince people who are hesitant to get inoculated.

Operation Warp Speed Chief Adviser Moncef Slaoui urged Americans on Friday to look at the numbers that show the efficacy of Pfizer and BioNTech’s vaccine.

“We have to go out there and engage with all of the leadership at all levels in our communities to help explain the features with of the vaccine, its performance, and hopefully engage with people and convince them,” Slaoui said. “Frankly, we couldn’t do it effectively before because we couldn’t be very specific.”

Slaoui emphasized that the experts reviewing the data on the Pfizer vaccine have concluded that the shot has “exceptional efficacy” and an “excellent safety profile that is comparable to many approved vaccines.”

A Pfizer spokesperson confirmed to CNN on Friday that an emergency use authorization had been granted, following the recommendation of the FDA’s Vaccines and Related Biological Products Advisory Committee.

The EUA allows officials to ship the vaccine doses, but shots still can’t be administered until the CDC’s Advisory Committee on Immunization Practices (ACIP) meets and recommends the vaccine.

The ACIP is scheduled to meet at 11 a.m. Saturday and vote on recommending the vaccine. The last step in the approval process would be the green light from the CDC. Injections could be administered in days.

Health and Human Services Secretary Alex Azar told ABC that the FDA would work with Pfizer to get the vaccine shipped “so we could be seeing people get vaccinated Monday, Tuesday of next week.”

Governors are prioritizing who would get the vaccines first in their states. Healthcare workers and the most vulnerable, including residents of long-term care facilities, are expected to be first in line.

States will receive shipments of Pfizer’s vaccine once a week to begin with after the shots are rolled out, Slaoui said.

The number of vaccines will increase “week-on-week” because manufacturing will ramp up, Slaoui said.

Governors will be notified a week in advance how many doses to expect, he said.

States and communities ramp up social restrictions

While the country anxiously awaits the first Covid-19 vaccine authorization, local and state leaders are responding to rising case rates by ramping up or extending social restrictions.

Citing increased hospitalizations across New York City, Gov. Andrew Cuomo on Friday announced that beginning next week dining rooms in eateries will be closed.

Outdoor dining and takeout may continue, he added.

Mississippi’s top health official, who said the state’s ICUs are full, issued an order to postpone some elective procedures.

In a tweet posted Friday afternoon, Dr. Thomas Dobbs said all elective surgeries requiring hospitalization will be postponed starting Tuesday.

Ohio Gov. Mike DeWine announced Thursday the state is extending its statewide curfew until January 2, saying officials believed the curfew so far, along with face masks, have had an impact.

In Florida, Miami said it will again enforce Miami-Dade County’s nightly curfew, starting this weekend, in response to a surge in coronavirus cases.

The county implemented the midnight-to-6 a.m. curfew earlier this year, but the city stopped enforcing it in October.

Cases, hospitalizations and deaths soar

While a green light for a Covid-19 vaccine will offer hope, leading experts have warned the worst days of the pandemic are still ahead for the US. More case surges are likely to take shape as a result of Thanksgiving travels, and future holiday gatherings could drive numbers even higher, they say.

Cases, hospitalizations and deaths already are soaring:

• The US has averaged 210,201 new Covid-19 cases daily over the past week – the highest average ever recorded for the country, according to Johns Hopkins University data.

• The US on Friday set another record for the number of Covid-19 patients in hospitals on a given day – 108,044, according to the COVID Tracking Project.

• Newly released data from the Department of Health and Human Services shows that more than 85% of hospitals nationwide had more patients with Covid-19 last week than they did a month ago.

• The county’s average number of deaths reported daily across a week was 2,259 Thursday, just below a pandemic peak reported a day before.

• This week also saw the most coronavirus deaths reported by the US in one day – 3,124, on Wednesday.

“We are in the time frame now that probably for the next 60 to 90 days, we’re going to have more deaths per day than we had in 9/11,” CDC director Dr. Robert Redfield said. “This is going to be a real unfortunate loss of life, as all that we’ve had so far, and the reality is the vaccine approval this week is not going to really impact.”

A CNN analysis of newly released data from the US Department of Health and Human Services showed that at least 200 hospitals across the US were at full capacity last week. And more than 90% of ICU beds were occupied in a third of all hospitals.

A timeline for the future

The US has been supporting the development of six other coronavirus vaccines besides the one from Pfizer and BioNtech.

One of them, from Moderna, may be in line for an emergency use authorization later this month. The FDA advisory panel is set meet next week to consider whether to recommend this.

Another, from GlaxoSmithKline and Sanofi Pasteur, will be delayed until at least late 2021 after interim results showed “insufficient immune response” in the elderly, the companies said Friday.

Azar told ABC on Friday that the GSK/Sanofi delay won’t affect the United States’ expectation about how many Americans will be vaccinated by early 2021.

“We’re looking at 20 million Americans being vaccinated just in the next coming weeks (and) up to 50 million total by the end of January,” he told ABC. “We believe we could have 100 million actual vaccinations in arm by the end of February.”

Hospital systems and pharmacies are preparing to administer vaccines to healthcare workers and residents of long-term care facilities, respectively.

At Chicago’s Rush University Medical Center, 10 vaccination stations have already been set up in a hallway, with temporary partitions. Hospital staff would get their Covid-19 vaccines there when doses arrive.

“I just feel like it’s a beginning of the end of this crazy pandemic, and it’s … nice to see it, frankly,” an RUMC respiratory therapist, Brady Scott, told CNN Friday. “It feels like a moment (where) we’re going to turn the curve and we’re going to get back to normal.”

It’s likely the US won’t see any meaningful, widespread impacts from vaccinations until well into 2021. But just how quickly the country can recover depends on how quickly Americans get vaccinated – and how many people are willing to get the vaccine.

“If we have a smooth vaccination program where everybody steps to the plate quickly, we could get back to some form of normality, reasonably quickly. Into the summer, and certainly into the fall,” Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, told CNN Thursday.

“My hope and my projection is that if we get people vaccinated en masse so that we get that large percentage of the population, as we get into the fall, we can get real comfort about people being in schools, safe in school – be that K-12, or college,” he added.

CNN’s Haley Brink, Elizabeth Cohen, Naomi Thomas, Deidre McPhillips, Adrienne Broaddus, Bill Kirkos, Amanda Watts, Melissa Alonso, Andrea Diaz and Tina Burnside contributed to this report.