CNN  — 

Thousands of vials of the long-awaited Covid-19 vaccine are slated to arrive in all 50 states Monday, as top US health officials express hope that health care workers can begin administering the injections immediately.

The news comes after the Pfizer-BioNTech Covid-19 vaccine cleared its final hurdle: Dr. Robert Redfield, director of the US Centers for Disease Control and Prevention, accepted an advisory committee’s recommendation Saturday that the vaccine may be given to people 16 and older, meaning it can now be administered in the United States.

In a statement issued Sunday, Redfield announced he had accepted the recommendation from the CDC’s Advisory Committee on Immunization Practices. The first vaccinations are “set to start as early as Monday,” he said.

“This is the next step in our efforts to protect Americans, reduce the impact of the Covid-19 pandemic, and help restore some normalcy to our lives and our country,” he said in a statement.

Boxes containing the Pfizer-BioNTech Covid-19 vaccine are prepared for shipping at the Pfizer Global Supply Kalamazoo manufacturing plant on December 13, 2020 in Michigan.

Dr. Stephen Hahn, commissioner of the US Food and Drug Administration, too, said his “greatest hope and desire” is that the vaccinations begin Monday.

“My hope, again, is that this happens very expeditiously, hopefully tomorrow,” Hahn told CNN on Sunday. “We’ve seen the vaccines go out. We’ve seen the press reports of hospitals waiting to vaccinate health care workers and those most vulnerable.”

The decision comes the same day that the first batch of vaccines was loaded onto trucks at a Pfizer plant in Portage, Michigan, and shipped out across the country.

Freight trucks carrying about 184,275 vials of vaccine departed the plant, and the combined 189 boxes of vaccine vials are expected to arrive in all 50 states Monday.

Another 3,900 vials are expected to ship later Sunday to United States territories, and 400 boxes packed with about 390,000 vials will ship Monday to arrive Tuesday. There are five doses of vaccine per vial, according to Pfizer.

The excitement surrounding the shipment even brought out small groups of cheering spectators. At Gerald R. Ford International Airport in Grand Rapids, Michigan, where the vaccine was loaded onto a FedEx cargo plane, Vicki Royce and her husband gathered outside the facility.

Covid-19 vaccines are packaged at the Pfizer facility in Portage, Michigan, on December 13, 2020.

“This is so exciting. This is history!” Royce said. “The first vaccines are going out. I’m like crying here.”

From its origin in Michigan, the Pfizer/BioNTech vaccine will arrive to about 600 sites across the US in the coming days.

“It’s a very good day for America – and for the world,” Moncef Slaoui, head of US coronavirus vaccine efforts, told Fox News Sunday.

The FDA granted emergency use authorization to the vaccine Friday, and the CDC’s ACIP voted Saturday to recommend it for people age 16 and older. The CDC vaccine advisory committee recommended that health care workers and long-term care facility residents be first in line to receive the shot.

The US plans to distribute 40 million vaccine doses by year’s end, followed by 50 to 80 million doses in January and in February, according to Slaoui.

“All in all, we hope to have immunized 100 million people” by the end of the first quarter of 2021, Slaoui said on Fox News Sunday.

The vaccine arrives at a critical moment for the US. Covid-19 hospitalizations hit record highs for the seventh day in a row Saturday. With the winter holidays still ahead, experts warn that the pandemic could continue to get worse before the larger public receives the vaccination.

Covid-19 vaccines are packaged at the Pfizer facility on Sunday.

Experts including Hahn and members of the CDC’s ACIP have said they have faith in the evaluation of the vaccine.

“I do believe that the process that we have used here in the ACIP to reach this decision is transparent, is science based, keeps equity in mind and is, for this moment, the absolute best that we can do,” said ACIP member Dr. Beth Bell, a clinical professor of global health at the University of Washington.

American Medical Association President Dr. Susan Bailey said in a statement Saturday the biggest obstacle to the vaccine is people’s willingness to be vaccinated.

“To be clear, these vaccines will reduce death and severe illness. They have been rigorously evaluated, and if enough of us roll up our sleeves and get vaccinated, we can eventually reclaim normalcy,” she said.

Surge on top of surge

Most Americans will have to wait months before they can get the vaccine, and until then many states are expected to continue experiencing unprecedented numbers of new infections.

For the 12th consecutive day, there were more than 100,000 Covid-19 patients in US Hospitals, according to the COVID Tracking Project, with a record 109,331 patients on Sunday.

Arizona reported its second highest number of new cases Saturday with 8,076, and reached a new record positivity rate at 25%, indicating that the viral transmission is increasing faster than the case counts indicate, according to an ongoing study by the University of Arizona’s Zuckerman College of Public Health.

The California Department of Public Health reported 35,729 new coronavirus cases on Saturday, breaking the previous record set on Friday of 35,468 new cases.

For three consecutive days, Florida reported more than 10,000 cases a day before reporting 8,964 cases Sunday, a CNN tally shows. The state has reported 7,000 or more new cases every day this month.

With the fallout of Thanksgiving travel and gatherings still unfolding, health officials warn the impacts to communities could soon get worse.

Los Angeles County Public Health Director Barbara Ferrer issued a grim warning about the coming weeks, after announcing Friday that the county has doubled its number of daily new cases in about 10 days.

“The issue right now is what we call the Thanksgiving surge,” Ferrer said. “We had a surge, and now we have a surge on top of a surge, and it’s really hard for us to calculate exactly what we’re going to see in the next week or two.”

“We’re on a very dangerous track to see unprecedented and catastrophic suffering and death here in L.A. County if we can’t stop the surge,” Ferrer said.

Overburdened hospitals across the US

The average number of new daily cases over the last week was 210,764, another pandemic high, according to a CNN analysis of Johns Hopkins data.

Hospitals across the country have felt the impact. Data from the US Department of Health and Human Services shows more than 85% of hospitals had more Covid-19 patients last week than they did a month ago. Overall, about one in five hospital inpatients were confirmed to have Covid-19 last week – nearly double the number from a month earlier.

In the country’s 10 largest cities, the share of hospital patients who had the virus ranged from about 9% in New York to 23% in Chicago. In El Paso, Texas, more than 50% of patients in city hospitals had Covid-19 between November 27 and December 3. That’s nearly double the national average for that period.

As of Saturday, there were more than 13,000 Covid-19 patients in California hospitals, a record for the state and a 3.5% increase compared to the day before, according to the California Department of Public Health. The state also reported a record 35,729 new cases.

Correction: An earlier version of this story misstated the number of coronavirus vaccine doses that the US plans to distribute by the end of the year. It is 40 million.

CNN’s Eliott C. McLaughlin, Dakin Andone, Dianne Gallagher, John Bonifield, Christina Maxouris, Lauren Mascarenhas, Artemis Moshtaghian, Melissa Alonso, Maggie Fox, Haley Brink, Andrea Diaz, Shelby Lin Erdman, Jamie Gumbrecht, Kay Jones, Deidre McPhillips, Pete Muntean, Alta Spells, Greg Wallace and Chuck Johnston contributed to this report.