New York CNN Business  — 

US airlines have canceled thousands of flights for Wednesday and Thursday as a powerful winter storm packing ice, rain, sleet and snow is stretching from the Midwest to the South.

For Wednesday, Chicago O’Hare, a United and American Airlines hub, is the most affected airport with 364 cancellations, according to flight tracking site FlightAware. St. Louis, Denver and Detroit airports are also accumulating cancellations with 352 as of Wednesday night. In total, airlines have canceled 2,350 US flights Wednesday.

Thursday appears to be even worse, with FlightAware data showing US airlines have canceled at least 3,563 flights within, into, or out of the United States for that day. Nearly 90% of scheduled flights from Dallas Love Field, a Southwest hub, have already been canceled. The airline has already cut 26% of its schedule for Thursday. Dallas Fort Worth, another American Airlines hub, has 375 cancellations.

Airlines issue travel waivers letting travelers rebook for free when severe weather impacts operations. CNN Travel has a guide about what to do if your flight is affected.

Ice accumulation is expected across the South, including in the Dallas-Fort Worth region and Memphis, with effects that could linger into the weekend. Overall, more than 90 million people are under winter weather alerts that stretch from the Rockies to New England.

“A corridor of heavy ice accumulation (exceeding a quarter of an inch) is likely from Texas through the Ohio Valley,” the Weather Prediction Center said early Wednesday. “Locations impacted by snow and/or ice are expected to have temperatures remain below freezing, and well below average for at least a couple of days after the wintry precip(itation) ends.”

It’s been a miserable few weeks to be an airline traveler, especially after last weekend’s storm that complicated travel. Winter weather and Omicron surges left 20,000 US flights canceled over the busy holiday travel season. As travel picked up, staffing cuts also left airlines with fewer employees than they had before the pandemic.