First, Shericka Jackson set a new national and championship record after beating Shelly-Ann Fraser-Pryce to gold.
The Jamaican dominated the race and won in a time of 21.45 seconds -- becoming the second fastest woman of all-time behind only American Florence Griffith-Joyner.
It was shortly followed by Noah Lyles retaining his title in the men's race and smashing the American record previously set by Michael Johnson 26 years ago.
Lyles is now the third fastest man over the distance after clocking in at 19.31 seconds.
"Today is my day. I finally got to do what I dreamed of," Lyles said after the race. "I felt I got the best start I could possibly ask for."
He was joined on the podium by two fellow Americans -- Kenny Bednarek in second and teenager Erriyon Knighton in third -- as the US became the first country to complete the clean sweep of World Championship medals in both the men's 100m and 200m.
"It's an immaculate feeling to be on the podium with two fellow Americans," Lyles added.
'Best we've ever seen'
While not completing the full sweep in the women's race, Jamaica did complete the 1-2 with Jackson and Fraser-Pryce way ahead of Great Britain's Dina Asher-Smith in third.
Johnson, who saw his record beaten by Lyles, was working as a pundit for the women's race and said the quality was the "best we've ever seen."
"I'm feeling great. I came out and put on a show," world champion Jackson said. "The fastest woman alive, the national and championship record, I can't complain."