The Al-Quds Hospital in Gaza received three evacuation orders on Friday, according to the Palestinian Red Crescent.
Earlier on Friday, the hospital's administration said the Israeli army had contacted them, demanding the immediate evacuation of the hospital in preparation for a nighttime airstrike.
The Israel Defense Forces called the Palestinian Red Crescent three times between 7 p.m. and 11 p.m. local time on Friday, its director general, Marwan Jilani, told CNN on Friday.
"It was the same threat, it was 'evacuate immediately,'" Jilani said.
Jilani said the hospital had received evacuation orders in the past, but emphasized the ones on Friday seemed "really serious."
Al-Quds Hospital currently houses more than 400 patients and approximately 12,000 displaced civilians who have sought refuge there as a safe haven, according to the Palestinian Red Crescent.