American Airlines is suspending most long-haul international flights from the US between March 16 and May 6, said the airline in a news release.
Demand has plummeted amid virus concerns and new US government travel restrictions.
The airline is reducing its international capacity by 75% compared to last year.
It will only continue three long-haul international routes: one flight a day from Dallas to London, one from Miami to London, and three flights a week from Dallas to Tokyo.
Short-haul international flights, like those from the US to Canada, Mexico, the Caribbean, Central America, and certain parts of South America will continue.
Domestic flights are not immune, however. The airline anticipates its domestic capacity in April will be reduced by 20% compared to last year, and the number could fall to 30% by May on a year-over-year basis.