More than 300 households in the Berlin district of Neukoelln have been placed into quarantine, after 57 new infections were registered.
Christian Berg from the Neukoelln Town Hall told CNN that seven apartment buildings had been affected in the densely populated district in the capital.
Germany's response to the pandemic has been widely praised, with only 8,840 deaths due to the virus relative to its population of more than 80 million people.
Chancellor Angela Merkel has received particular credit for installing a rigorous testing regime early on while showing effective and compassionate leadership.
She, along with French President Emmanuel Macron, have taken the lead on the European Union's response to the virus, steering the bloc towards agreeing a €500 billion recovery package.