A pill people usually taken to prevent blood clots helped reduce the risk of heart attacks, strokes and other problems caused by blood clots in hospital patients, researchers reported Monday.
They gave the drug, sold under the brand name Xarelto, to 4,900 patients who had been treated and then sent home from the Feinstein Institutes at New York’s large Northwell Health hospital system.
They gave placebos to 4,900 other discharged coronavirus patients. Each group was followed for about six weeks.
Patients given Xarelto, known generically as rivaroxaban, had a 28% reduced risk of a blood clot in the leg, known as a deep vein thrombosis, Northwell’s Alex Spyropoulos and colleagues reported in the Journal of the American College of Cardiology. And their risk of other blood clots known as venous thromboembolisms, heart attacks, strokes or other types of heart death were 28% lower than patients who went home with dummy pills.
The patients were on average about 68 years old, and there didn’t seem to be an increase in bleeding problems – a known side effect of the drug.
“We are encouraged by the study’s results to potentially reduce these life-threatening thromboembolic episodes by expanding the use of rivaroxaban for patients post-hospitalization,” Spyropolous said in a statement. “Through this research, Northwell Health has adapted its treatment policy for discharged COVID-19 patients, and others at risk, across the health system.”
Increased blood clotting throughout the body is a known symptom of coronavirus infection, and doctors have been trying out various blood thinners in patients to see if they can help safely.