The Mississippi State Department of Health reported 1,092 new coronavirus cases Thursday.
This is the highest single-day increase since case tracking began, the Health Department's Office of Communications confirmed to CNN.
Five new deaths were also reported Thursday.
At least 536 people are currently hospitalized and 50 new cases have been identified in long-term care facilities. There are 86 active outbreaks in long-term care facilities, according to the report.
There have been a total of 24,516 coronavirus cases and a total of 1,016 deaths reported in the state.