Certain safety elements, including the possibility of vaccine-induced enhancement of infection, will be paid special attention in the Phase 3 trials of Covid-19 vaccines, Dr. Anthony Fauci, the nation’s top infectious disease expert, said during a webinar Wednesday with the TB Alliance.
Phase 1 data gives you immediate safety, not necessarily all the parameters, and Phase 2 gives you more, Fauci said, but as they go into Phase 3, which is fundamentally efficacy to see if it works in the field, “we are also going to pay a special attention to certain safety elements.”
One of these, he said, is they “want to keep a special eye on is the possibility of vaccine-induced enhancement of infection.”
Fauci explained that this is when “you get vaccinated, you get infected, and the fact that you have been vaccinated with a level, an inadequate level, of suboptimal antibodies, that you can actually enhance the infection, because you’ve been vaccinated.”
He said they want to, and will, keep an eye on this in Phase 3 trials.
Fauci said that he doesn’t have a particular reason to believe this will be a problem, but as they have seen these kind of issues before, he wants to pay attention to it.
“I don’t use the word ‘I’m worried about it.’ Rather than worry, I try to do something about it,” he said.