The latest on the coronavirus pandemic and vaccines

The US has recorded an average of about 1.5 million Covid-19 tests per day over the past week, according to data from The COVID Tracking Project.

That’s about 26% fewer than the average in mid-January, when the US hit a peak seven-day average of more than 2 million tests reported on Jan. 15.

The decline in new tests reported nationally had been rather consistent since hitting that peak. But over the past seven days, the number of new tests reported has started to tick back up.

The average of about 1.5 million tests per day over the past week is a 14% increase over the average of about 1.3 million tests per day the week before.

Even as case rates drop, experts have stressed the importance of testing as a way to stay ahead of outbreaks, particularly with the new variants in the mix.

Contract tracing, which requires sufficient testing, is also one of five key mitigation strategies outlined by the US Centers for Disease Control and Prevention in school reopening guidance.

More on the testing data: Reported test counts are estimates. Also, states do not all report tests consistently. Some include both viral (PCR) and antigen tests, and some report based on the number of people tested as opposed to the number of specimens tested.

France has extended the upper age limit for use of the Oxford/AstraZeneca coronavirus vaccine, now approving use of the vaccine in 65 to 75 year olds with serious health conditions, the country’s health minister announced Monday. 

The decision comes after a previous warning from the government that AstraZeneca’s Covid-19 vaccine should only be administered in people under the age of 65, citing a lack of clinical data on its efficacy for older people.

Speaking to France 2 TV, the health minister said the French National health authority now considers all vaccines available in France, including the AstraZeneca, Pfizer and Moderna vaccines, to “have an effectiveness qualified as ‘remarkable’ in protecting people from the risks of serious forms of coronavirus.” 

While coronavirus restrictions are still in place across the country, Veran also suggested that the government would consider easing measures over the coming weeks. 

"We obviously hope that in four to six weeks, we can have more freedom,” Veran said. 

“We did this last year. Spring is less conducive to the circulation of the virus. We vaccinate, we protect the most vulnerable, we keep our fingers crossed,” he added. 

Two doses of coronavirus vaccine protect people better against coronavirus variants than just one dose, CDC experts said Monday.

The B.1.351 variant first seen in South Africa has the most worrying effects on the ability of vaccines to produce an immune response, the CDC’s Dr. Heather Scobie told a meeting of the CDC’s Advisory Committee on Immunization Practices.

But there are concerns about the B.1.1.7 variant first seen in the UK, as well as a variant common in Brazil known as P2.

She said the CDC has reviewed many of the studies – some published, others released as unreviewed pre-prints – on how the variants allow the virus to evade immune responses.

“Five studies have shown that postponing the second mRNA dose may leave some people less protected against the SARS-Cov-2 variants,” Scobie told the ACIP meeting. The Moderna and Pfizer/BioNTech vaccines are mRNA vaccines.

“All of the studies showed improved neutralization of B.1.1.7 and B.1.351 after the second vaccine dose,” she added. “In a few studies, people who had recovered from Covid-19 and received one vaccine dose had moderate protection against B.1.351.”

There are indications that people’s immune responses grow stronger over time after vaccination, Scobie said.

 “Antibody responses to B.1.1.7 and B.1.351 improved slightly by week three,” she said. 

Real-life studies also give some clues about how well the vaccines will protect people from the variants. 

“The Pfizer vaccine was shown to have high real world effectiveness of 86% against symptomatic and asymptomatic disease in the UK and 84% against symptomatic disease in Israel during times when B.1.1.7 was prevalent,” Scobie said.

Protection provided by the one-dose Johnson & Johnson vaccine varied from 74% in the US to 66% in Brazil at a time when most cases were caused by the P2 variant. During clinical trials in South Africa, where the B.1.351 variant was almost the only circulating virus, Johnson & Johnson vaccine efficacy was 52%. But that’s against mild to moderate disease. It provided between 73% and 82% efficacy against severe disease no matter which variant was the most common.

“Importantly, the Janssen vaccine demonstrated similar vaccine efficacy against severe, critical disease across all three countries,” Scobie said.

The first shipment of Covid-19 vaccines sent through the COVAX program to Latin America landed in Colombia on Monday afternoon, the Pan American Health Organization (PAHO) announced.

The shipment of 117,000 Pfizer vaccine doses landed at El Dorado Airport in Bogota in the afternoon local time, the Colombian government said in a statement. The doses will be transferred to Ministry of Health warehouses to be stored.

COVAX is an entity run by a coalition that includes the Vaccine Alliance known as Gavi and the World Health Organization (WHO), and is funded by donations from governments, multilateral institutions and foundations.

It aims to buy coronavirus vaccines in bulk and send them to poorer nations that can't compete with wealthy countries in securing contracts with the major drug companies.

Colombia now has at least 409,620 vaccine doses; the country previously received 100,620 doses through a deal with Pfizer and 192,000 doses from Sinovac.

Colombia expects to receive a total of 61.5 million doses of the vaccine, 20 million doses through the deal with COVAX and 41.5 million from various pharmaceutical companies, a government statement said. 

COVAX shipments are still expected in other Latin American countries including Argentina, Brazil, Peru, Mexico, among many others.

To achieve herd immunity, the Colombian government hopes to vaccinate 70% of the country’s population, around 35,734,649 people. 

Colombia currently has at least 2,251,690 confirmed cases of Covid-19 and 59,766 recorded deaths, according to data from Johns Hopkins University.

Senate Majority Leader Chuck Schumer said that “this week” the Senate will take up the $1.9 trillion American Rescue Plan.

Some context: The House passed their own version of the Covid relief bill early Saturday morning. If the Senate passes their version of the bill by the end of the week, that gives the House time to re-pass the new version in their own chamber.

It also gives President Biden time to sign it and gives states an opportunity to readjust their unemployment benefits with the increased benefit. Biden and Democrats are rushing to meet their deadline of having enacted the bill by March 14 when a weekly federal enhancement in benefits is scheduled to expire.

Lawmakers have reached an agreement to return most California students to classrooms by the end March.

The agreement combines proposals from Gov. Gavin Newsom and from California’s legislature and will provide up to $6.6 billion to return schools to in-person learning.

Of that, $2 billion will be made available to those schools that bring students back by March 30.

Schools will be eligible for their part of the $2 billion incentive once they resume classes for at least those students in transitional kindergarten through second grade. 

The rest of the funding, $4.6 billion, is aimed at helping schools make up for lost learning time, or as Newsom calls it, “reimagining the school year” which could include longer school days and/or summer school. 

Ultimately, the reopening decisions lay with the superintendents of each district, not the state. The funding, which is mainly earmarked for personal protective equipment, improved ventilation, and other safety protocols, may well provide the incentive districts need.

Some teachers unions, including United Teacher Los Angeles (UTLA), which represents educators in Los Angeles Unified School District (LAUSD), have balked at resuming classes until teachers have the chance to be vaccinated.

Starting today, the pool of those eligible to receive a vaccine in Los Angeles has expanded to include educators.

LAUSD, the nation’s second largest district, has secured 25,000 vaccine doses for teachers and staff, which will be initially focused on inoculating those already working at school sites, preschool, and elementary teachers, according to Superintendent Austin Beutner.

In the meantime, UTLA’s membership is voting today on whether they will agree to return before staff is provided with full access to vaccinations and safety conditions are in place.

The agreement specifies that districts can resume class regardless of whether the unions sign off.

The three Federal Emergency Management Agency vaccination sites in Texas are expected to receive 24,000 doses of the Johnson & Johnson Covid-19 vaccine on Tuesday, according to Lara Anton, a press officer for the Texas Department of State Health Services.

It’s not yet clear if the doses will be administered on Tuesday.

More than 200,000 Johnson & Johnson doses are expected be available to Texas for next week’s allocation, Anton said.

Of the 3.9 million doses of the single-shot Johnson & Johnson vaccine being distributed by the federal government, the Association of Immunization Managers said Monday that they will be distributed as follows:

The US Food and Drug Administration on Monday granted emergency use authorization to the Quidel QuickVue At-Home Covid-19 Test.

Dr. Jeff Shuren, director of the FDA’s Center for Devices and Radiological Health, said in a statement that “The FDA continues to prioritize the availability of more at-home testing options in response to the pandemic.”

Here are some key things to know about the at-home test:

Rapid antigen tests have been shown to be less accurate than RT-PCR tests, which are considered the “gold-standard” of diagnostic testing.

In a press release, Quidel said the test can return results in as little as 10 minutes, and that positive test results match PCR tests 84.8% of the time; negative test results match PCR results 99.1% of the time.

The sample swabs are placed in a test tube along with a test strip. Colored lines on the test strip indicate a positive or negative test result, similar to a home pregnancy test.

In a separate news release Monday, the National Institutes of Health announced it is evaluating the use of Quidel’s QuickVue test with a smartphone app. The agency says it has enrolled more than 200 participants in the study, which requires them to use the test daily for two weeks.

The NIH says that as at-home tests become more widely available, it believes companion apps will play a role in tracking symptoms, administering tests and reporting results to public health authorities and health care providers.

“Understanding how individuals interact with these apps and where they find value in them will inform future efforts to advance at-home COVID-19 testing,” the NIH said in a statement.

The US military has administered 1,144,697 doses out of 1,275,925 doses delivered to the military so far. At least 735,000 of those are initial doses, 409,000 are second doses, Pentagon spokesperson John Kirby said. 

The US military expects to get doses of the Johnson & Johnson vaccine delivered to them in “the next week or so,” now that it has been approved by the FDA for Emergency Use Authorization, Kirby said.

Kirby acknowledged that the Secretary is aware of vaccine hesitancy in some pockets of the military, particularly “cultural and community concerns,” he said.

Right now, the Pentagon has not decided whether or not to make the Covid-19 vaccine mandatory when it does receive full authorization from the FDA. The Pentagon cannot make the vaccine mandatory currently because it has been authorized under emergency use by the FDA.

“These are still under emergency authorization, and so right now, they are not mandatory. Obviously, we’re thinking about what happens when they become FDA approved,” Kirby said.