The first freight trucks carrying approximately 184,275 vials of the vaccine have departed Pfizer on Sunday.
Trucks carrying a combined 189 boxes of vaccine vials are expected to arrive in all 50 states on Monday.
Another 3,900 vials are expected to ship later today to US territories.
On Monday, another 400 boxes packed with approximately 390-thousand vials will ship for arrival on Tuesday.
Watch as first doses of vaccine ship out from Pfizer facility: